This atlas explores the latest advances in radionuclide imaging in the field of inflammatory diseases and infections, which now typically includes multimodality fusion imaging (e.g. in SPECT/CT and in PET/CT). In addition to describing the pathophysiologic and molecular mechanisms on which the radionuclide imaging of infection/inflammation is based, the clinical relevance and impact of such procedures are demonstrated in a collection of richly illustrated teaching cases, which describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Special emphasis is placed on using tomographic multimodality imaging to increase both the sensitivity and specificity of radionuclide imaging. The aim of the second edition of this book is to update the first (published in 2013) by reflecting the changes in this rapidly evolving field. Particular attention is paid to the latest advances in the radionuclide imaging of infection and inflammation, including the expanding role of hybrid imaging with [18F]FDG PET/CT SPECT/CT, without neglecting new radiotracers proposed for the imaging of infection/inflammation. Written by respected experts in the field, the book will be an invaluable tool for residents in nuclear medicine, as well as for other specialists. “A major didactic value is in the representation, in each illustrated case … . The reader, both younger and the most experienced, has the opportunity to understand or refresh the pathophysiological bases … . this atlas allows an excellent training on the use of techniques and in the interpretation of images acquired with radionuclide procedures. It can result very useful not only to nuclear physicians and radiologists, but also to clinicians … .” (Milena Masone and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 48, 2021) This atlas explores the latest advances in radionuclide imaging in the field of inflammatory diseases and infections, which now typically includes multimodality fusion imaging (e.g. in SPECT/CT and in PET/CT). In addition to describing the pathophysiologic and molecular mechanisms on which the radionuclide imaging of infection/inflammation is based, the clinical relevance and impact of such procedures are demonstrated in a collection of richly illustrated teaching cases, which describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Special emphasis is placed on using tomographic multimodality imaging to increase both the sensitivity and specificity of radionuclide imaging. The aim of the second edition of this book is to update the first (published in 2013) by reflecting the changes in this rapidly evolving field. Particular attention is paid to the latest advances in the radionuclide imaging of infection and inflammation, including the expanding role of hybrid imaging with [18F]FDG PET/CT SPECT/CT, without neglecting new radiotracers proposed for the imaging of infection/inflammation. Written by respected experts in the field, the book will be an invaluable tool for residents in nuclear medicine, as well as for other specialists. Elena Lazzeri Elena Lazzeri specialized in Nuclear Medicine at the University of Pisa (Italy) and did her PhD in 2009 at the University Medical Center Groningen, Groningen (The Netherlands). Since 1995 she is Adjunct Professor for the Postgraduate Specialty in Nuclear Medicine at the University of Pisa, as well as lecturer at several teaching courses for Continuing Medical Education in Nuclear Medicine throughout Italy since 2002. Among other activities, she is responsible for “Diagnosis of Infectious Diseases” at the Regional Center of Nuclear Medicine, University Hospital of Pisa, Pisa (Italy), Expert Consultant of the International Atomic Energy Agency (IAEA), Vienna (Austria), Teacher at the European School of Nuclear Medicine (ESNM) for Theoretical and Practical Courses on “Infection and Inflammation”, certified speaker of the European School of Multimodality Imaging and Therapy (ESMIT) and Senior Advisor of the EANM Committee on “Infection and Inflammation”. Her main research interests are: Imaging infection and inflammation with particular emphasis to orthopedic infections, Fever of Unknown Origin, and cardiovascular infections with standard imaging techniques and with novel molecular imaging agents. She is member of several national and international scientific societies, among them the European Association of Nuclear Medicine (EANM), the International Research Group in Immunoscintigraphy and Immuno-Therapy (IRIST) and the International Society of Radiolabelled Blood Elements (ISORBE). Dr. Lazzeri has authored/co-authored over 40 articles in international peer-reviewed journals and over 15 invited chapters in books; she has also co-edited one book. Alberto Signore Prof. Alberto Signore is presently working at the Department of Medical-Surgical Sciences and of Translational Medicine