Methylation Support - A modified methylated B complex with L-serine and TMG, which are known to facilitate the efficient metabolism of homocysteine and normal methylation.* Promotes Heart & Brain Health - An optimally functioning homocysteine pathway plays a role in biochemical reactions, such as detoxification, healthy immune support, ideal joint and cartilage structure, brain health and cardiovascular health.* Premium B Vitamins & TMG for Superior Absorption - Supplies a methylated folate and B12 supplement, along with P5P vitamin B6 and riboflavin. Includes Trimethylglycine to support normal methylation.* Vegetarian & Non-GMO - Vegetarian-friendly and made without soy, gluten, GMOs or soy. Take 2 capsules per day with meals or as directed by your health-care practitioner. Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.** Homocysteine Supreme, a methylated multivitamin for men and women contains synergistic nutrients, including a folate supplement in the bioidentical, bioactive form, 5-methyltetrahydrofolate, known to facilitate the efficient metabolism of homocysteine. This methylated vitamin B supplement maintains a healthy homocysteine pathway, allowing for the normal production of its necessary and important end products. These include the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine. An optimally functioning homocysteine pathway provides methyl and sulfur groups for biochemical reactions, such as detoxification, healthy immune function, ideal joint and cartilage structure/joint support, and brain health and cardiovascular health, and thus is sometimes used as a supportive brain health supplement. Also includes vit B6 as B6 P5P, methylated folate and B12 supplements. Folate supplement for women and men.*