Until recently, CT scanner performance was limited by a series of compromises. With single-detector scanners, one cannot select thin collimation and still maintain the required extent of volumetric coverage. Slow scans cause motion artifacts that impair image quality. The introduction of multidetector CT technology, however, has revolutionized the field. Currently multidetector, multislice CT scanners acquire up to four channels of data from interweaving spirals. The minimum gantry rotation period is as low as half of a second. This increased scan speed allows for thinner collimation and thus higher longitudinal or z-axis resolution in comparison with single-detector CT. The improved image quality with multidetector technology leads to new applications of CT, particularly in cardiac, vascular, and abdominal imaging. On-going clinical studies are evaluating the suitability of this new imaging tool for non-invasive screening and diagnosis of coronary artery disease. A particular advantage to the increased scan speed in vascular imaging is the ability to cut intra­ venous contrast dosage and still maintain peak enhancement CT throughout the entire acquisition. Thin-section, multiphasic acquisition during optimal arterial-phase and venous-phase enhan­ cement significantly improves the accuracy for small lesion and vessel detection, and enhances overall classification of abdominal neoplasms. On the other hand, the increasingly large volume data sets force to new ways of looking at, presenting, storing, and trans­ ferring images. Networking and two- and three dimensional data processing are the key words. The twin developments of spiral CT and multidetector array technology have opened a new era. The CT scanner performance is substantially improved because of increased speed and isotropic spatial resolution. This has yielded a broadening of the spectrum of applications, particularly in cardiac, vascular and abdominal imaging. However, a practical challenge of multidetector CT is the need to select a wide variety of user-selectable parameters in the effort to produce an optimal study. The handling of huge data sets represents another important task. This book contains the experiences of an international group of experts and it is designed to provide the requisite background knowledge in multidetector CT.