In 1957 two young scientists Matthew Meselson and Frank Stahl produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability excitement intellectual challenge and serendipitous windfalls as well as its frustrations unexpected diversions away from original plans and chronic uncertainty. Holmes uses research logs experimental films correspondence and interviews with the participants to record the history of Meselson and Stahl's research from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment the experiment's influence on later investigations and the reasons for its reputation as an exceptionally beautiful experiment. "Holmes has written a remarkable history of one of molecular biology's most significant experiments." -- David Baltimore, president, California Institute of Technology "Holmes meticulously shows how science is done." -- Alfred Tauber, Boston University Frederic Lawrence Holmes is chairman and Avalon Professor of History of Medicine at Yale University.